HLA3DB

The Human Leukocyte Antigen Structure Database

A curated, up-to-date database of Human Leukocyte Antigen (HLA-I) structural data from the PDB.

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What is HLA3DB?

The HLA3DB (Human Leukocyte Antigen) database is an auto-curated repository containing the pHLA structures encompassing class I HLA alleles. The database employs an internal coordinate-based algorithm to classify HLA structures according to the conformation of the displayed peptide backbone. This allows us to identify common trends across peptide sequences presented by different HLA allotypes, serving as a toehold for understanding the molecular basis of antigen receptor cross-reactivity.

How to use HLA3DB?

The user can browse and search for structures of peptide/HLAs of interest. All collections of structures and statistics in HLA3DB are available for download. Users can reference the manuscript for more information.

HLA3DB

Summary statistics of the database:

Number of PDB entries with an HLA structure: 551
Number of alleles: 56
Number of unique backbone classifications: 101
Number of PDB entries with 8mer peptides: 31
Number of PDB entries with 9mer peptides: 416
Number of PDB entries with 10mer peptides: 104